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Late-onset spinocerebellar degeneration
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HP_0006904 |
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Spastic hemiparetic gait
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HP_0031957 |
[Spastic hemiparesis is characterized by a dominance of the tonus in the upper limb flexor muscles: the arm is held in an adducted posture and is bent and rotated inwards, the forearm is pronated and the hand and the fingers are flexed. The leg is slightly bent at the hip, the knee cannot be extended fully at the end of the stance phase and the foot is inverted and in a plantar flexed position. Gait is slow, with a wide base and asymmetrical with a shortened weight-bearing phase on the paretic side. During the swing phase, the paretic leg performs a lateral movement (circumduction) which is characteristic of this gait disorder, also termed Wernicke-Mann gait. Spastic gait problems typically worsen on attempts to walk faster.] |
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Spastic gait
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HP_0002064 |
[Spasticity is manifested by increased stretch reflex which is intensified with movement velocity. This results in excessive and inappropriate muscle activation which can contribute to muscle hypertonia. Spastic gait is characterized by manifestations such as muscle hypertonia, stiff knee, and circumduction of the leg.] |
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Abnormality of amino acid metabolism
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HP_0004337 |
[Abnormality of an amino acid metabolic process.] |
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Basal ganglia gliosis
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HP_0006999 |
[Focal proliferation of glial cells in the basal ganglia.] |
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Antalgic gait
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HP_0031955 |
[To avoid pain weight is put on the affected leg for as short a time as possible, resulting in a limp. The patients appear to be walking as if there were a thorn in the sole of the foot. To reduce the load on the affected leg the patients lift and lower their foot in a fixed ankle position.] |
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Elevated circulating aspartate aminotransferase concentration
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HP_0031956 |
[The concentration of aspartate aminotransferase (AST) in the blood circulation is above the upper limit of normal.] |
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Cautious gait
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HP_0031953 |
[Cautious gait refers to an excessive degree of age-related changes in walking and fear of falling. The walking difficulties seem out of proportion when considering the patient's actual sensory or motor deficits. The gait appears slow, with a wider base than normal, reduced arm swing bilaterally and a slightly stooped posture. This type of gait change often occurs after the first time a patient has fallen.] |
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Bone-marrow foam cells
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HP_0004333 |
[The presence of foam cells in the bone marrow, generally demonstrated by bone-marrow aspiration or biopsy. Foam cells have a vacuolated appearance due to the presence of complex lipid deposits, giving them a foamy or soap-suds appearance.] |
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Dystonic gait
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HP_0031954 |
[Dystonic gait disorders frequently appear bizarre, particularly because activity increases dystonic tonus and posture. The abnormal posture of the foot in dystonic gait typically involves inversion, plantar flexion and tonic extension of the big toe. In many patients complex types of walking, such as walking backwards and running are paradoxically less impaired than walking forward and may seem completely unaffected. Sensory tricks, for instance, if the affected individual rests a hand on his or her neck, may improve or even normalize dystonic gait in some patients.] |
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Myelin outfoldings
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HP_0004336 |
[The presence of excessive redundant myelin in the peripheral nerve sheath.] |
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Nocturnal seizures
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HP_0031951 |
[Seizures that occur while the affected individual is sleeping.] |
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Neurogenic claudication
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HP_0031952 |
[Lumbar spinal stenoses may induce symptoms following an individually typical latency on standing or when walking due to swelling of the cauda equina, which leads to compression. This is referred to as neurogenic claudication. The symptoms of lumbar spinal stenosis can be explained by an increase in lumbar lordosis and spinal canal stenosis in an upright position compared to the sitting position or if spondylolisthesis is present by a shift of the vertebrae while standing and walking. Following an individually characteristic distance, walking becomes associated with deep muscular pain and with neurological deficits, such as sensory deficits and paresis in the lower limbs, which resolve within minutes when the affected person sits or lies down. Activities performed in a flexed posture, such as cycling often cause less problems than walking. For the same reason, walking uphill may be tolerated better than walking downhill. Clinical neurological examination at rest may be entirely normal but there is usually pain on hyperextension of the lumbar spine.] |
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nucleus pulposus cell of intervertebral disc
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CL_0002564 |
[A connective tissue cell of the nucleus pulposus cell of intervertebral disc.] |
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Diffuse leukoencephalopathy
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HP_0006994 |
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Anterior basal encephalocele
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HP_0006992 |
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Myelin-dependent gliosis
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HP_0006990 |
[A type of gliosis that occurs in the vicinity of injured neurons.] |
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Leg dystonia
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HP_0031959 |
[A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the legs.] |
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Usual interstitial pneumonia
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HP_0031950 |
[Temporal and spatial heterogeneity in lungs based on presence of fibrosis and honeycombing.] |
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mesenchymal stem cell of umbilical cord
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CL_0002569 |
[A mesenchymal stem cell of the umbilical cord.] |