All terms in HP

Label Id Description
pulmonary collagen fibril UBERON_0011862 [The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity.]
bone collagen fibril UBERON_0011863 [The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity.]
aorta collagen fibril UBERON_0011861 [The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity.]
obsolete Acral ulceration and osteomyelitis leading to autoamputation of the digits (feet) HP_0001862
Abnormal Th17 T cell proportion HP_0025830 [Abnormal increase or decrease of Th17 cells, commonly characterized through the intracellular synthesis of IL-17 or surface expression of CCR6, measured as proportion of total CD3+CD4+ T cells, usually after stimulation. The stimulation is usually unspecific and may include the use of anti-CD3 beads or antibodies, the use of phorbol-12-myristate-13-acetate (PMA) with ionomycin, or staphylococcal enterotoxin B (SEB). Length of incubation and strength of stimulation may vary between laboratories.]
Clinodactyly of the 5th toe HP_0001864 [Bending or curvature of a fifth toe in the tibial direction (i.e., towards the big toe).]
Decreased PMA/ionomycin-induced T-cell proliferation HP_0025833 [Abnormal decrease of T cell proliferation in response to phorbol-12-myristate-13-acetate (PMA) and ionomycin stimulation. This is commonly measured through intracellular expression of Ki67, decreasing surface expression of carboxyfluorescein diacetate (CFSE), or 3H-thymidine incorporation. Length of incubation and strength of stimulation may vary between laboratories.]
Decreased mitogen-induced T-cell proliferation HP_0031381 [Abnormal decrease of T cell proliferation in response to mitogenic stimuli. This is commonly measured through intracellular expression of Ki67, decreasing surface expression of carboxyfluorescein diacetate (CFSE), or 3H-thymidine incorporation. Length of incubation, specific stimulus and strength of stimulation may vary between laboratories.]
regulation of cell differentiation involved in embryonic placenta development GO_0060800 [Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state.]
Decreased PHA-induced T-cell proliferation HP_0025834 [Abnormal decrease of T cell proliferation in response to stimulation with phytohaemagglutinin. This is commonly measured through intracellular expression of Ki67, decreasing surface expression of carboxyfluorescein diacetate (CFSE), or 3H-thymidine incorporation. Length of incubation and strength of stimulation may vary between laboratories.]
Increased Th17 T cell proportion HP_0025831 [Abnormal increase of Th17 cells, commonly characterized through the intracellular synthesis of IL-17 or surface expression of CCR6, measured as proportion of total CD3+CD4+ T cells, usually after stimulation. The stimulation is usually unspecific and may include the use of anti-CD3 beads or antibodies, the use of phorbol-12-myristate-13-acetate (PMA) with ionomycin, or staphylococcal enterotoxin B (SEB). Length of incubation and strength of stimulation may vary between laboratories.]
Decreased Th17 T cell proportion HP_0025832 [Abnormal decrease of Th17 cells, commonly characterized through the intracellular synthesis of IL-17 or surface expression of CCR6, measured as proportion of total CD3+CD4+ T cells, usually after stimulation. The stimulation is usually unspecific and may include the use of anti-CD3 beads or antibodies, the use of phorbol-12-myristate-13-acetate (PMA) with ionomycin, or staphylococcal enterotoxin B (SEB). Length of incubation and strength of stimulation may vary between laboratories.]
negative regulation of cell differentiation involved in embryonic placenta development GO_0060806 [Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state.]
Abnormal RTE CD4+ T cell proportion HP_0025837 [Abnormal increase or decrease of the recent thymic emmigrant (RTE) CD4+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, with the necessary expression of CD31+, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.]
Increased RTE CD4+ T cell proportion HP_0025838 [Abnormal increase of the recent thymic emmigrant (RTE) CD4+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, with the necessary expression of CD31+, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.]
Decreased CD8+ T cell degranulation HP_0025835 [Abnormal decrease of CD8-positive T cell degranulation in response to stimulation, commonly measured through surface CD107a expression in response to cocultivation with a murine cell line. Other methods may be used by different laboratories.]
Increased CD8+ T cell proportion HP_0025836 [Abnormal increase of cytotoxic CD3+CD8+ T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.]
Decreased RTE CD4+ T cell proportion HP_0025839 [Abnormal decrease of the recent thymic emmigrant (RTE) CD4+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, with the necessary expression of CD31+, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.]
Autoamputation of foot HP_0001868 [The spontaneous detachment of a foot from the body due to long standing pathology.]
Deep plantar creases HP_0001869 [The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot.]