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Severe temper tantrums
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HP_0025162 |
[Temper tantrums, which occur with more severe symptomatology compared to a temper tantrum that occurs as a part of normal developmental process.] |
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Clumping of elastic fibers in the dermis
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HP_0025165 |
[Formation of clumps or aggregates that make up small protuberances from elastic fibers within the dermis (especially the reticular dermis).] |
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Thickened elastic fibers in the dermis
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HP_0025166 |
[An increase of the diameter of elastic fibers in the dermis.] |
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Increased number of elastic fibers in the dermis
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HP_0025164 |
[An elevated number of elastic fibers, that is of bundles of proteins and glycoproteins in the extracellular matrix in the reticular dermis. Elastic fibers can stretch and recoil back to their original length. This feature can be appreciated on histology with hematoxylin and eosin or other staining methods.] |
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L-proline
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CHEBI_17203 |
[Pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles.] |
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Hypergranulosis
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HP_0025114 |
[Hypergranulosis is an increased thickness of the stratum granulosum.] |
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Civatte bodies
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HP_0025115 |
[Eosinophilic hyaline ovoid bodies which are often found in the subepidermal papillary regions or sometimes in the epidermis. Civatte bodies (CBs) are seen as rounded, homogenous, eosinophilic masses on routine H and E staining lying in the deeper parts of epidermis/epithelium and more frequently in dermis/connective tissue. They are known as CBs (in epithelium/epidermis), colloid bodies, or hyaline bodies (in connective tissue). They are 10-25 micrometers in diameter and situated mostly within or above the inflammatory cell infiltrate. In lichen planus, the number of necrotic keratinocytes may be so large that they are seen lying in clusters in the uppermost dermis. These bodies show a positive periodic acid Schiff reaction and are diastase resistant] |
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Lattice corneal dystrophy
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HP_0001149 |
[The presence of fine, branching linear opacities in Bowman's layer in the central area that may spread to the periphery in the clinical course. The deep corneal stroma may be involved but the process does not reach Descemet's membrane. Recurrent corneal erosion may occur. Histologic examination reveals amyloid deposits in the collagen fibers of the cornea.] |
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Auditory sensitivity
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HP_0025112 |
[Decreased tolerance to sound.] |
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Misophonia
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HP_0025113 |
[Misophonia is characterized by strong physiological, emotional, and behavioral reactions to auditory, visual, and/or kinesthetic stimuli of different nature regardless of their physical characteristics. These misophonic responses include anger, general discomfort, disgust, anxiety, and avoidance and escape behaviors.] |
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Lip discoloration
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HP_0025118 |
[Lightening or darkening of the lips from their usual coloring.] |
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Violet lip discoloration
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HP_0025119 |
[An alteration of the color of the lip to take on a violet color. This term does not include cyanosis.] |
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obsolete Chorioretinopathy
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HP_0001145 |
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Fetal distress
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HP_0025116 |
[An intrauterine state characterized by suboptimal values in the fetal heart rate, oxygenation of fetal blood, or other parameters indicative of compromise of the fetus. Signs of fetal distress include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile.] |
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obsolete Pigmentary retinal degeneration
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HP_0001146 |
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Rete ridge flattening
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HP_0025117 |
[Rete pegs (or ridges) are the epithelial extensions that project into the underlying connective tissue in both skin and mucous membranes. Rete ridge flattening refers to the loss of these projections so that the skin epithelium acquires a relatively flat appearance.] |
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Limbal dermoid
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HP_0001140 |
[A benign tumor typically found at the junction of the cornea and sclera (limbal epibullar dermoid).] |
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Severely reduced visual acuity
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HP_0001141 |
[Severe reduction of the ability to see. On the 6m visual acuity scale, severe reduction is defined as less than 6/60 but at least 3/60. On the 20ft visual acuity scale, severe reduction is defined as less than 20/200 but at least 20/400. On the decimal visual acuity scale, severe reduction is defined as less than 0.1 but at least 0.05.] |
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Lenticonus
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HP_0001142 |
[A conical projection of the anterior or posterior surface of the lens, occurring as a developmental anomaly.] |
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Placoid macular lesion
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HP_0025110 |
[Large yellow/white, sharply delineated lesion, typically of inflammatory nature, involving the macula, more specifically at the outer retinal level (RPE/photoreceptor).] |