Eye of the tiger anomaly of globus pallidus
Go to external page http://purl.obolibrary.org/obo/HP_0002454
The presence, on T2-weighted magnetic resonance imaging, of markedly low signal intensity of the globus pallidus that surrounds a central region of high signal intensity in the anteromedial globus pallidus, producing an eye-of-the-tiger appearance. The sign is thought to represent iron accumulation in the globus pallidus. [ http://www.ncbi.nlm.nih.gov/pubmed/29371252 http://www.ncbi.nlm.nih.gov/pubmed/19881070 https://orcid.org/0000-0002-0736-9199 http://www.ncbi.nlm.nih.gov/pubmed/11110959 ]
Term information
- UMLS:C4025705
This sign is observed upon magnetic resonance tomography (MRI). It can be seen in several diseases including Hallervorden-Spatz syndrome, where the pathophysiology has been hypothesized to be related to iron deposition in the globus pallidus (associated with low signal intensity on T2-weighted images) accompanied by other pathological processes such as gliosis and water accumulation that are responsible for the high signal intensity at the central globus pallidus.
Term relations
- has part some (
increased amount and
characteristic of some (
iron atom and
part of some globus pallidus) and
has modifier some abnormal)