An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as "simple spikes," and climbing fibres, which modulate infrequent calcium spike activity known as "complex spikes". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress. [ http://www.ncbi.nlm.nih.gov/pubmed/31424738 http://www.ncbi.nlm.nih.gov/pubmed/12907269 http://www.ncbi.nlm.nih.gov/pubmed/33288911 http://www.ncbi.nlm.nih.gov/pubmed/38168772 MESH:D011689 http://www.ncbi.nlm.nih.gov/pubmed/14568361 ]

Synonyms: Purkinje neuron cerebellar Purkinje cell

This is just here as a test because I lose it

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Neurodegenerative disorders affecting Purkinje cells disrupt motor functions. Some of the neurodegenerative disorders that causes loss and degeration of Purkinje cells are Spinocerebellar ataxias (SCAs) (Josef P Kapfhammer and Etsuko Shimobayashi 2023), Friedreich's ataxia (FRDA) (Kevin C Kemp et al., 2016), Fetal alcohol syndrome (Laurent Servais et al., 2016), Dandy-Walker malformation (Alexander Atamian et al., 2024).