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Formycin
|
DB02281 |
|
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Nardostachys chinensis whole
|
DB14269 |
[Nardostachys chinensis whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Aminopentamide
|
DB15597 |
|
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Tribulus terrestris root
|
DB14266 |
[Tribulus terrestris root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Momordica charantia fruit
|
DB14265 |
[Momordica charantia fruit is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Aminopromazine
|
DB15596 |
|
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MIV-711
|
DB15599 |
|
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Swertia japonica whole flowering
|
DB14268 |
[Swertia japonica whole flowering is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
|
Rumex crispus whole
|
DB14267 |
[Rumex crispus whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Ferric maltol
|
DB15598 |
|
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Bird pepper
|
DB14262 |
[Bird pepper is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Golodirsen
|
DB15593 |
[Golodirsen is a morpholino antisense oligomer designed to treat about 8% of patients with Duchenne Muscular Dystrophy (DMD). This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood, rendering many patients wheelchair-bound by age 12. Often, patients succumb to this condition by age 30 or younger due to cardiac and respiratory complications.[A188580,T756] A similar drug used in the treatment of other types of DMD is [eteplirsen], which targets a different genetic mutation.[L10773]
Golodirsen was developed by Sarepta Therapeutics and granted accelerated FDA approval on December 12, 2019 due to the urgent need for this drug in patients suffering from a certain form of DMD. Continued approval of this drug will depend on the results of clinical trials that confirm its clinical benefit.[L10755,L10758] Golodirsen was initially rejected for FDA approval over concerns about its potential renal toxicity, however, clinical trials did not show significant toxicity.[L10755]] |
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Cucurbita pepo subsp. ovifera whole
|
DB15592 |
|
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Panax ginseng fruit
|
DB14261 |
[Panax ginseng fruit is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
|
Ebola Zaire vaccine (live, attenuated)
|
DB15595 |
[Ebola virus vaccine is a vaccine used to prevent Ebola virus disease caused by _Zaire ebolavirus_ in adults, prevent outbreaks, and reduce the extent of the virus spreading in case of outbreaks.[L10854] Ebola virus disease, formerly known as Ebola hemorrhagic fever, is a rare but severe and often deadly disease. It is highly contagious: human to human transmission occurs from contact with body fluids from infected patients.[A189024] It is characterized by fever, headache, myalgia, and gastrointestinal symptoms. These may be accompanied by hypotension and respiratory, kidney and liver failure, as well as internal and external bleeding.[A188994,A188997] In the _Filoviridae_ family, there are five unique Ebolavirus species that are each named after the geographical region where it was first identified. The mortality rate of the Zaire species is about 80%.[A188997]
Confirmed outbreaks of Ebola virus disease have been documented since the 1970s, mostly in Sub-Saharan Africa, where Ebola first appeared in 1976 near the Ebola River in Zaire (presently referred to as the Democratic Republic of the Congo) and Sudan.[A188994] Between 2014 and 2016, Ebola outbreaks occurred in West Africa, leading to more than 11,310 total deaths during this time in Guinea, Liberia, and Sierra Leone.[A188997] In 2016, this epidemic was exhausted after these countries were declared Ebola-free by 2016, and the World Health Organization (WHO) lifted the Public Health Emergency of International Concern (PHEIC) status on the West Africa Ebola outbreak.[L10884]
The first live, attenuated Ebola virus vaccine was developed by a team of Canadian researchers at Canada’s National Microbiology Laboratory and was later patented by the Canadian government.[L10866] In non-human primate clinical trials, the vaccine was effective in inducing an immune response against the Ebola viruses.[A189018] This vaccine was later sold to NewLink Genetics, a biotech company that held the license to the vaccine from 2010 to 2014, although the vaccine was not marketed.[L10866] In 2014, Merck Inc. signed a licensing agreement with NewLink for further development and marketing. Ervebo, the marketed Ebola virus vaccine by Merck, was first approved by the European Commission in November 2019 after the European Medicines Agency recommended it be licensed. In December 2019, Ervebo was approved by the FDA in the United States. Ervebo consists of an envelope glycoprotein of the Zaire ebolavirus (Kikwit 1995 strain) fused into a vesicular stomatitis virus (VSV) backbone.[L10854] By introducing the relatively inactive viral protein to the patient, the patient’s immune system learns to recognize and attack the virus if he or she is exposed to it in the future.] |
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Maclura tricuspidata whole
|
DB14264 |
[Maclura tricuspidata whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
|
Calendula officinalis flower
|
DB14263 |
[Calendula officinalis flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
|
Brilliant blue G
|
DB15594 |
[Brilliant Blue G is used in an ophthalmic solution for staining the internal limiting membrane (ILM) of the eye during ophthalmic procedures.[A188841,A188844] This membrane is thin and translucent, making it difficult to identify during eye surgeries that require high levels of visual accuracy. Brilliant blue G, like its name, imparts a vibrant blue color, facilitating identification of the ILM. It was approved by the FDA for ophthalmic use on December 20, 2019.[L10830]] |
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Atrial natriuretic peptide
|
DB15591 |
|
|
Stypocaulon scoparium
|
DB14260 |
[Stypocaulon scoparium is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |