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Butyric Acid
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DB03568 |
[A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.] |
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Maltotetraose
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DB02237 |
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4,5-Dehydro-L-Iduronic Acid
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DB03569 |
|
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4-(Methylsulfanyl)-2-Oxobutanoic Acid
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DB02238 |
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Nesiritide
|
DB04899 |
[Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide.] |
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Ximelagatran
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DB04898 |
[Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary restrictions, drug interaction, and monitoring issues associated with the former. In 2006, its manufacturer AstraZeneca announced that it would not attempt to market ximelagatran after reports of hepatotoxicity (liver damage) during trials, and to discontinue its distribution in countries where the drug had been approved.] |
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Spermidine
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DB03566 |
[Spermidine is a polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.] |
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L-methionine (R)-S-oxide
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DB02235 |
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alpha-N-Acetyl-D-galactosamine
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DB03567 |
[The N-acetyl derivative of galactosamine. [PubChem]] |
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Glycinamide Ribonucleotide
|
DB02236 |
|
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Lucinactant
|
DB04897 |
[Lucinactant is a new synthetic peptide-containing surfactant for intratracheal use. It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P). More specifically, it mimics the C-terminal amphipathic helical domain of this protein. It also consists of phospholipids (dipalmitoylphosphatidylcholine, DPPC and palmitoyloleoyl phosphatidylglycerol, POPG) and a fatty acid (palmitic acid). It is completely devoid of animal-derived components. FDA approved on March 6, 2012.] |
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Milnacipran
|
DB04896 |
[Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the additional indication of treating fibromyalgia [F3925], although other regional regulatory authorities like the EMA, among others, have not yet approved the agent for such treatment, citing lack of robust evidence of efficacy, insufficient demonstration of maintenance of effect, and other concerns [F3928, F3934]. Nevertheless, milnacipran demonstrates a somewhat unique characteristic among SNRIs to elicit a relatively balanced reuptake inhibition of both serotonin and noradrenaline, with a somewhat increased preference for noradrenaline reuptake inhibition - which is potentially a point of interest given the plausible proposal that noradrenaline plays an important role in the mitigation of pain signals in the descending inhibitory pain pathways in the brain and spinal cord [A175759, A175843, A175846].
Moreover, recent research has shown that the levorotatory enantiomer of milnacipran, levomilnacipran, may have the capacity to inhibit the activity of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), which has investigationally been associated with β-amyloid plaque formation - making the agent a possible course of treatment for Alzheimer's disease [A175957].] |
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6-hydroxy-D-norleucine
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DB02233 |
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(4r)-2-Methylpentane-2,4-Diol
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DB03564 |
|
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S-Ethylisothiourea
|
DB02234 |
[S-Ethylisothiourea is a nitric oxide synthase inhibitor.] |
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1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine
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DB03565 |
|
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Pegaptanib
|
DB04895 |
[Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability.] |
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Vapreotide
|
DB04894 |
[Vapreotide is a synthetic octapeptide somatostatin analog. It was being studied for the treatment of cancer.] |
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Tetrahydrodeoxyuridine
|
DB03562 |
|
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1,2-Dihydroxybenzene
|
DB02232 |
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