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Tegaserod
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DB01079 |
[Novartis' brand name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of irritable bowel syndrome with constipation (IBS-C) [L5918, F4229]. It was, however, voluntarily withdrawn from widespread use in the US market in 2007 after concerns arose over the possibility that tegaserod could potentially cause dangerous cardiovascular events in patients [L5918, F4229]. Since then, closer evaluations of the original data suggesting such cardiovascular risk have resulted in the limited reintroduction or 're-approval' of tegaserod for treatment of IBS-C specifically in female patients less than 65 years of age and whom are considered to be at a lower risk of a cardiovascular event than the broader population [L5918, F4229]. Zelnorm (tegaserod) by Sloan Pharma subsequently gained re-approval in April of 2019 [L5918]. Nevertheless, tegaserod remains un-approved in certain regions [F4226].
Despite the relative complications involved in its history of regulatory approval, ever since its first introduction in 2002 tegaserod remains the only therapy for IBS-C that possesses the unique mechanism of action of acting on serotonin-4 (5-HT(4)) receptors in smooth muscle cells and in the gastrointestinal wall to facilitate actions like esophageal relaxation, peristaltic gut movement, and natural secretions in the gut, among others [L5918, A11044, A176762, F4229, F4223].] |
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Deslanoside
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DB01078 |
[Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.] |
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AZD-0424
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DB13088 |
[AZD0424 has been used in trials studying the treatment of Advanced Solid Tumours.] |
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Enoxolone
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DB13089 |
[Enoxolone (glycyrrhetic acid) has been investigated for the basic science of Apparent Mineralocorticoid Excess (AME).] |
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Pyritinol
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DB13084 |
[Pyritinol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders.] |
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Riamet
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DB13085 |
[Riamet has been investigated for the treatment of Malaria, Malaria, Falciparum, Malaria in Pregnancy, Uncomplicated Malaria, and Uncomplicated Knowlesi Malaria.] |
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SCYX-7158
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DB13086 |
[SCYX-7158 has been used in trials studying the treatment of Trypanosomiasis, Parasitic Diseases, Protozoan Infections, and Trypanosomiasis, African.] |
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Miridesap
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DB13087 |
[Miridesap has been used in trials studying the prevention of HIV.] |
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Roluperidone
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DB13080 |
[Roluperidone has been used in trials studying the treatment of Schizophrenia.] |
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Nefiracetam
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DB13082 |
[Nefiracetam has been used in trials studying the treatment of Alzheimer's Disease.] |
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Talarozole
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DB13083 |
[Talarozole has been investigated for the treatment of Psoriasis and Cutaneous Inflammation.] |
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Valnoctamide
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DB13099 |
[Valnoctamide has been used in trials studying the treatment of Mania and Schizoaffective Disorder, Manic Type.] |
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JTK-853
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DB13095 |
[JTK-853 has been used in trials studying the treatment of Hepatitis C Virus Infection, Response to Therapy of.] |
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Gacyclidine
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DB13096 |
[Gacyclidine has been used in trials studying the treatment of Tinnitus.] |
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1alpha-Hydroxyvitamin D5
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DB13097 |
[1alpha-Hydroxyvitamin D5 (CARD-024) has been used in trials studying the treatment of Drug Safety and Heart; Disease, Activity.] |
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CT-2584
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DB13098 |
[CT-2584 has been used in trials studying the treatment of Prostate Cancer.] |
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Tiropramide
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DB13091 |
[Tiropramide is under investigation in clinical trial NCT01629212 (Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome).] |
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Meclocycline
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DB13092 |
[Meclocycline is under investigation in clinical trial NCT00385515 (Efficacy of SNX-1012 in the Treatment of Oral Mucositis) [L797].] |
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TAK-593
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DB13093 |
[TAK-593 has been used in trials studying the treatment of Solid Tumors.] |
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Pruvanserin
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DB13094 |
[Pruvanserin has been used in trials studying the treatment of Sleep Initiation and Maintenance Disorders.] |
