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Metyrapone
|
DB01011 |
[An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.] |
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2,3-Dihydroxy-Valerianic Acid
|
DB03675 |
|
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Edrophonium
|
DB01010 |
[A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.] |
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Clobetasol propionate
|
DB01013 |
[A derivative of prednisolone with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than fluocinonide, it is used topically in treatment of psoriasis but may cause marked adrenocortical suppression.] |
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9-N-Phenylmethylamino-Tacrine
|
DB03672 |
|
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Mdl 101,146
|
DB02341 |
|
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2-Methoxyestradiol
|
DB02342 |
[2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.] |
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Beta(2-Thienyl)Alanine
|
DB03673 |
|
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Cinacalcet
|
DB01012 |
[Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.] |
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2-deoxy-2-fluoro-alpha-D-mannosyl fluoride
|
DB02318 |
|
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[{(5-Chloro-2-Pyridinyl)Amino} Methylene]-1,1-Bisphosphonate
|
DB03649 |
|
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5,6-dihydroxy-NADP
|
DB02319 |
|
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AVR118
|
DB04979 |
[AVR118 represents a new type of biopolymer chemistry that also possesses novel immunomodulator activity. This non-toxic peptide-nucleic acid, which to date has shown no indication of human toxicity, appears to stimulate the proinflammatory responses required to combat viral infections such as AIDS and human papilloma virus and to dampen aberrant autoimmune-type inflammatory responses. AVR118 is being studied for the promise shown in its ability to mitigate the toxic side effects of other drugs (including those used to treat HIV infection and chemotherapeutic drugs employed in the treatment of cancers); for its ability to stimulate the immune system to attack tumor cells (especially those cancer cells that have been damaged by chemotherapeutic agents) and for its ability to treat cachexia (wasting) in patients with AIDS or cancer.] |
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3-[Isopropyl(4-Methylbenzoyl)Amino]-5-Phenylthiophene-2-Carboxylic Acid
|
DB03647 |
|
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1-(5-Carboxypentyl)-5-[(2,6-Dichlorobenzyl)Oxy]-1 H-Indole-2-Carboxylic Acid
|
DB02316 |
|
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(2S,2'S)-2,2'-(1,2-Hydrazinediylbis{methylene[(2S)-1-oxo-2,1-hexanediyl]imino})bis(6-amino-N-phenylhexanamide)
|
DB03648 |
|
|
Alpha-D-Galactose-1-Phosphate
|
DB02317 |
|
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SP1049C
|
DB04978 |
[SP1049C is a novel anthracycline chemotherapeutic agent designed to overcome drug resistance in a number of cancers. It has successfully completed Phase 1 trials. Phase 2 results are currently under final review. Preliminary data, in its first clinically tested indication, shows that SP1049C is active in Stage IV non-resectable adenocarcinoma of the oesophagus. Median survival is encouraging and correlates strongly with dose levels.] |
|
Plitidepsin
|
DB04977 |
[Aplidine is a peptide found in tunicates which shows promise in shrinking tumors in pancreatic, stomach, bladder, and prostate cancers. The specific marine organism is _Aplidium albicans_. Aplidine is also of interest as a potential treatment for some leukemias.] |
|
Phosphonoacetohydroxamic Acid
|
DB03645 |
|
