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4-hydroxyphenacyl coenzyme A
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DB03613 |
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LX201
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DB04943 |
[LX201 is a silicone matrix ocular implant that provides sustained release of cyclosporine A (CsA) locally to the eye over the course of one year. LX201 is implanted subconjunctivally (beneath the transparent membrane covering the white of the eye) in a minimally invasive procedure. The implant is being developed clinically for the prevention of rejection in corneal transplantation. It is being developed by Lux Biosciences, Inc.] |
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Tamibarotene
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DB04942 |
[Tamibarotene is a novel synthetic retinoid for acute promyelocytic leukaemia (APL). Tamibarotene is currently approved in Japan for treatment of recurrent APL, and is undergoing clinical trials in the United States.] |
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4-(trifluoromethyl)phenol
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DB03610 |
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L-2-amino-4-methoxy-cis-but-3-enoic acid
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DB03611 |
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Crofelemer
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DB04941 |
[Crofelemer, previously known as the investigational drug SP-303, is a novel proanthocyanidin purified from the bark latex of the Amazonian Croton tree <i>Croton lechleri</i>. It is marketed under the brand name Fulyzaq and indicated for the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.] |
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XL784
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DB04991 |
[XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because of its important role in blood vessel formation and cell proliferation. XL784 was specifically optimized to be MMP-1 sparing, thus potentially enhancing its safety profile and enabling higher dosing compared with other previously studied metalloprotease inhibitors. Results of single dose Phase I clinical trials of XL784 administered orally to 96 healthy volunteers have demonstrated that XL784 has attractive safety and pharmacokinetic profiles. It is being developed by Exelixis, Inc.] |
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4-Iodo-L-phenylalanine
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DB03660 |
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Macadamia seed oil glycereth-8 esters
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DB14318 |
[Macadamia seed oil glycereth-8 esters is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Pomegranate
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DB14317 |
[Pomegranate is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Magnolia kobus flowering top
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DB14319 |
[Magnolia kobus flowering top is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Indigofera tinctoria leaf
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DB14314 |
[Indigofera tinctoria leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Lawsonia inermis leaf
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DB14313 |
[Lawsonia inermis leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Tangerine peel
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DB14316 |
[Tangerine peel is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Calendula officinalis whole
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DB14315 |
[Calendula officinalis whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Argan oil
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DB14310 |
[Argan oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Glycyrrhiza glabra
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DB14312 |
[Glycyrrhiza glabra is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Shea butter
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DB14311 |
[Shea butter is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.] |
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Busulfan
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DB01008 |
[Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.] |
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Tioconazole
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DB01007 |
[Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.] |