|
Clorindione
|
DB13275 |
[Clorindione is a vitamin K antagonist, which may be useful to decrease prothrombin levels in humans.] |
|
Idanpramine
|
DB13276 |
|
|
Benziodarone
|
DB13277 |
[Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout [A175630]. It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients [T487, A175636].] |
|
Bucetin
|
DB13278 |
[Bucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication [A175636].] |
|
Wood creosote
|
DB13271 |
|
|
Meladrazine
|
DB13272 |
|
|
Sultopride
|
DB13273 |
[Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics [L5626].] |
|
Micronomicin
|
DB13274 |
[Micronomicin is an aminoglycoside antibiotic which is marketed in Japan, and sold under the brand names Sagamicin and Luxomicina.] |
|
Dibekacin
|
DB13270 |
[Dibekacin is an aminoglycoside antibiotic marketed in Japan [L5623].] |
|
Practolol
|
DB01297 |
[A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias.] |
|
Glucosamine
|
DB01296 |
[Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. It is an amino sugar and precursor of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.] |
|
Sulfadoxine
|
DB01299 |
[A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.] |
|
Sulfacytine
|
DB01298 |
[Sulfacytine is a short-acting sulfonamide. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections.
Sulfacytine is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.] |
|
Carbaphosphonate
|
DB02592 |
|
|
Desonide
|
DB01260 |
[A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.] |
|
7,8-Dihydroxy-1-Methoxy-3-Methyl-10-Oxo-4,10-Dihydro-1h,3h-Pyrano[4,3-B]Chromene-9-Carboxylic Acid
|
DB02593 |
|
|
Decitabine
|
DB01262 |
[Decitabine is indicated for treatment of patients with myelodysplastic syndrome (MDS). It is a chemical analogue of cytidine, a nucleoside present in DNA and RNA. Cells in the presence of Decitabine incorporate it into DNA during replication and RNA during transcription. The incorporation of Decitabine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence. This adversely affects the way that cell regulatory proteins are able to bind to the DNA/RNA substrate.] |
|
Abequose
|
DB02590 |
|
|
5,6-Dimethylbenzimidazole
|
DB02591 |
|
|
Sitagliptin
|
DB01261 |
[Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[Label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[Label,A2255]. Sitagliptin was granted FDA approval on October 16, 2006[L6061].] |