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Sapitinib
|
DB12183 |
[Sapitinib has been used in trials studying the treatment and basic science of Neoplasms, Breast Cancer, Breast Neoplasms, Metastatic Cancer, and Metastatic Breast Cancer, among others.] |
|
Gepirone
|
DB12184 |
[Gepirone has been used in trials studying the treatment of Cocaine-Related Disorders.] |
|
Exatecan
|
DB12185 |
[Exatecan has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Lung Cancer, and Liver Cancer, among others.] |
|
Apitolisib
|
DB12180 |
[Apitolisib has been used in trials studying the treatment of Solid Cancers, Breast Cancer, Prostate Cancer, Renal Cell Carcinoma, and Endometrial Carcinoma, among others.] |
|
Dalcetrapib
|
DB12181 |
[Dalcetrapib is under investigation for the treatment of Acute Coronary Syndrome.] |
|
ATP
|
DB00171 |
[An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.] |
|
Menadione
|
DB00170 |
[A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.] |
|
Adenine
|
DB00173 |
[A purine base and a fundamental unit of adenine nucleotides.] |
|
Proline
|
DB00172 |
[Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons.] |
|
Fasinumab
|
DB12157 |
[Fasinumab has been used in trials studying the basic science and treatment of Sciatica, Back Pain, Low Back Pain, Osteoarthritis, Hip, and Abdominal Pain Upper, among others.] |
|
Bencyclane
|
DB13488 |
[A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels.] |
|
Bamipine
|
DB13489 |
|
|
Filorexant
|
DB12158 |
[Filorexant has been used in trials studying the prevention and treatment of Migraine, Headache, Polysomnography, Diabetic Neuropathy, Painful, and Major Depressive Disorder, Recurrent.] |
|
Dupilumab
|
DB12159 |
[Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways.[A180478] As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that induce inflammatory and immunological reactions in several atopic or allergic conditions, such as eczema, allergic reaction, and rhinosinusitis.[A180478] Dupilumab was generated by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture.[L7186]
Dupilumab is commonly marketed as Dupixent®, which is available as a formulation for subcutaneous injection. It was first approved by the FDA in 2017 for patients 12 and older with eczema or atopic dermatitis. Dupilumab is also approved by Health Canada for the same indication and the European Commission for use in atopic dermatitis as well as severe asthma with type 2 inflammation.[L7225] It is the first biologic therapy to have been approved for the treatment of adult patients with moderate-to-severe AD in the EU and USA.[A180484] In 2018, FDA approved the use of dupilumab as an add-on maintenance treatment for patients 12 years and older with moderate-to-severe eosinophilic asthma or with oral corticosteroid-dependent asthma. In June 2019, dupilumab was also approved by the FDA as a treatment for inadequately controlled chronic rhinosinusitis with nasal polyps in adult patients.[L7258] Dupilumab is currently under investigations for potential therapeutic use in diseases driven by allergic reactions or type 2 inflammation, such as pediatric atopic dermatitis, eosinophilic esophagitis, and chronic obstructive pulmonary disease. It is also being studied in combination with another antibody that which targets IL-33.[L7225]] |
|
Quinbolone
|
DB13484 |
|
|
Citicoline
|
DB12153 |
[Citicoline is a donor of choline in biosynthesis of choline-containing phosphoglycerides. It has been investigated for the treatment, supportive care, and diagnostic of Mania, Stroke, Hypomania, Cocaine Abuse, and Bipolar Disorder, among others.] |
|
Itacitinib
|
DB12154 |
[Itacitinib has been used in trials studying the treatment of Melanoma, Carcinoma, Metastatic Cancer, Endometrial Cancer, and B-cell Malignancies, among others.] |
|
Sulfametomidine
|
DB13485 |
|
|
Napabucasin
|
DB12155 |
[Napabucasin has been investigated for the treatment of Colorectal Carcinoma.] |
|
Magnesium peroxide
|
DB13486 |
|
