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Relatlimab
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DB14851 |
[Relatlimab is under investigation in clinical trial NCT02966548 (Safety Study of BMS-986016 With or Without Nivolumab in Patients With Advanced Solid Tumors).] |
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Metergoline
|
DB13520 |
[Metergoline is an ergot-derived psychoactive drug that acts as a ligand for serotonin and dopamine receptors. Metergoline is an antagonist at various 5-HT receptor subtypes at a relatively low concentration and agonist at dopamine receptors [A27181]. Its use has been studied in various clinical settings such as a treatment for seasonal affective disorder, prolactin hormone regulation due to its inhibitory effect on prolactin release [A27182], premenstrual dysphoric disorder in women and antianxiety treatment [A27183].] |
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Deleobuvir
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DB14850 |
[Deleobuvir is under investigation in clinical trial NCT01983566 (Effect of Food and Increased Gastric pH Value on Bioavailability of a Single Dose of BI 207127 in Healthy Caucasian and Japanese Subjects).] |
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Oxyphenonium
|
DB00219 |
[A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of atropine. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect. [PubChem]] |
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2,3-Di-O-Sulfo-Alpha-D-Glucopyranose
|
DB02879 |
|
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Eletriptan
|
DB00216 |
[Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches.] |
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Drotebanol
|
DB01547 |
|
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Citalopram
|
DB00215 |
[Citalopram belongs to a class of antidepressant agents known as selective _serotonin-reuptake inhibitors_ (SSRIs) and is widely used to treat the symptoms of depression. Its chemical structure is unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other prescribed antidepressants [FDA label]. Citalopram is also known as _Celexa_, and available in tablet and solution forms [FDA label]. This drug was initially approved by the FDA in 1998 [L5230].] |
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Etryptamine
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DB01546 |
[In the 1960's, alpha-ethyltryptamine (αET), a non hydrazine reversible monoamine oxidase inhibitor, was developed in the United States by the Upjohn chemical company for use as an antidepressant. αET was an FDA approved antidepressant under the name Monase. However, in 1962, after the discovery of an unacceptable incidence of agranulocytosis, the development of Monase was halted and the drug was withdrawn from potential market use.
In 1993, the US Drug Enforcement Administration added αET to Schedule I of its Schedules of Controlled Substances, after an increasing incidence of its use as a recreational drug in the 1980's. Currently, αET is an illegal substance; however, it's activity is still under scientific investigation.
αET is a stimulant and hallucinogen, but it is less stimulating and hallucinogenic than alpha-methyltryptamine, a closely related compound. Instead, the effects of αET, a tryptamine derivative, more closely resemble the amphetamine derived drug 3,4-methylenedioxy-N-methylamphetamine (MDMA). Similarly to MDMA, αET has been shown to release serotonin pre-synaptically, as well as lesser amounts of norepinephrine and dopamine. Like MDMA, increases in locomotor activity and mood elevation can be seen post administration.] |
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Rolicyclidine
|
DB01549 |
[Rolicyclidine (PCPy) is classified as a dissociative anesthetic agent. It also has hallucinogenic and sedative properties. Because of its pharmacodynamic similarity to the drug phencyclidine (PCP), rolicyclidine was added to the Schedule I list of illegal drugs in the USA in the 1970s.] |
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Moxifloxacin
|
DB00218 |
[Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.] |
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Arotinoid acid
|
DB02877 |
[Arotinoid acid is a retinoic acid analog which acts as a selective RAR agonist.] |
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3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid
|
DB02878 |
|
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Diprenorphine
|
DB01548 |
[A narcotic antagonist similar in action to naloxone. It is used to remobilize animals after etorphine neuroleptanalgesia and is considered a specific antagonist to etorphine. [PubChem]] |
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Bethanidine
|
DB00217 |
[A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.] |
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CRA_1802
|
DB02875 |
|
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18-methyl-19-nortestosterone
|
DB01543 |
|
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Remikiren
|
DB00212 |
[Remikiren is an orally active, high specificity renin inhibitor.] |
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3-(4-Carbamoyl-1-Carboxy-2-Methylsulfonyl-Buta-1,3-Dienylamino)-Indolizine-2-Carboxylic Acid
|
DB02876 |
|
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Midodrine
|
DB00211 |
[An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.] |
