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L-thioproline
|
DB02846 |
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Furazabol
|
DB01514 |
|
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(2s,3r)-1-Amino-2-Methylbutane-2,3-Diol
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DB02847 |
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17Alpha-methyl-3beta,17beta-dihydroxy-5alpha-androstane
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DB01513 |
|
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3,4,5-Trimethoxyamphetamine
|
DB01516 |
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S-Adenosyl-1,8-Diamino-3-Thiooctane
|
DB02844 |
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Methylphosphinic Acid
|
DB02845 |
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Benzoylecgonine
|
DB01515 |
[Benzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after processing in the liver. It is the main pharmaceutical ingredient in the investigational drug Esterom, a topical solution used for the relief of muscle pain that is not FDA approved or on the market in the United States. [A18735]] |
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9-amino-n-[3-(dimethylamino)propyl]acridine-4-carboxamide
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DB02842 |
[9-amino-n-[3-(dimethylamino)propyl]acridine-4-carboxamide is an inactive derivative of the antitumour agents N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 9-amino-DACA.] |
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Dehydrochloromethyltestosterone
|
DB01510 |
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alpha-D-glucose-1-phosphate
|
DB02843 |
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Hydromorphinol
|
DB01512 |
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4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid
|
DB02840 |
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[(2-Ethoxy-1-Naphthoyl)Amino]Methylboronic Acid
|
DB02841 |
|
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Delorazepam
|
DB01511 |
[Delorazepam is a benzodiazepine which, like other drugs in its class, possesses anxiolytic, skeletal muscle relaxant, hypnotic and anticonvulsant properties. It may have adverse effects such as drowsiness, and cognitive impairments such as short term memory impairment. [4]
Delorazepam is an active metabolite of the benzodiazepine known as cloxazolam. It is a long acting benzodiazepine which makes it superior in this sense to lorazepam which is short acting. Lorazepam is also a major active metabolite of delorazepam.
In addition to be long acting, delorazepam is relatively potent, with 1 mg of delorazepam being the equivalent of 10 mg diazepam. It has been approved for marketing in Italy.] |
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6-hydroxyuridine-5'-phosphate
|
DB02890 |
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Sulfatolamide
|
DB13547 |
|
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Bergapten
|
DB12216 |
[Bergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis).] |
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Cefiderocol
|
DB14879 |
[Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam antibiotics.[FDA Label] Unlike other agents in this category, cefiderocol is a siderophore able to undergo active transport into the bacterial cell through iron channels.[A189057] It represents a significant addition to antibacterial treatment option as it has proven to be effective *in vitro* against multidrug resistant strains including extended spectrum β-lactamase producers and carbapenemase producing bacteria.
Cefiderocol was granted designation as a Qualified Infectious Disease Product and granted priority review status by the FDA on November 14, 2019.[L10893] It is indicated for use in complicated urinary tract infections in patients with limited or no alternative treatments available.[FDA Label] This indication was supported by a positive clinical trial composed of 448 patients with complicated urinary tract infections which demonstrated a 72.6% rate of symptom resolution and bacterial eradication with cefiderocol compared to 54.6% with the comparator, imipenem/cilastatin.[A189150] A concern noted in the trial was a 0.3% higher rate of all cause mortality, the cause of which has not been determined.] |
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Liafensine
|
DB14878 |
[Liafensine is under investigation in clinical trial NCT00892840 (Multiple-Ascending Dose Study).] |
