|
Pridinol
|
DB13642 |
|
|
CP1-1189
|
DB12311 |
[CPI-1189 has been used in trials studying the treatment of HIV Infections and AIDS Dementia Complex.] |
|
Pimodivir
|
DB14974 |
[Pimodivir is under investigation in clinical trial NCT02658825 (A Study to Evaluate the Effect of JNJ-63623872 on Cardiac Repolarization Interval in Healthy Participants).] |
|
Abrocitinib
|
DB14973 |
[Abrocitinib is under investigation in clinical trial NCT03796676 (JAK1 Inhibitor With Medicated Topical Therapy in Adolescents With Atopic Dermatitis).] |
|
Loprazolam
|
DB13643 |
[Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent nocturnal awakenings. Loprazolam is recommended as a short-term therapy only, due to adverse events associated with the drug including dependence and withdrawal symptoms. It is a positive modulator of GABA-A receptor that enhances the inhibitory neurotransmission. It is not an FDA-approved drug.] |
|
ORG-25435
|
DB12312 |
[Org 25435 has been used in trials studying the treatment of Anaesthesia.] |
|
Relacorilant
|
DB14976 |
[Relacorilant is under investigation in clinical trial NCT02804750 (Study to Evaluate CORT125134 in Patients With Cushing's Syndrome).] |
|
Dopexamine
|
DB12313 |
[Dopexamine has been used in trials studying the diagnostic and treatment of Free Flap, Oral Cancer, Hypotension, Septic Shock, and Head and Neck Cancer.] |
|
Methylthiouracil
|
DB13644 |
|
|
Ethacizine
|
DB13645 |
|
|
Chlorproguanil
|
DB12314 |
[Chlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide.] |
|
Voxelotor
|
DB14975 |
[Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications arising from the blockage of blood vessels.[T734]
Voxelotor was granted accelerated FDA approval on November 25 2019, as it likely to be a promising treatment for the 100,000 individuals in the U.S. suffering from the disease, in addition to 20 million others worldwide.[L10403] It was developed by Global Blood Therapeutics, Inc.[L10403] and is unique from other drugs used to treat sickle cell anemia, such as [hydroxyurea], [L-glutamine], and [crizanlizumab][A188135,A188138] due to its novel mechanism of action.] |
|
Alobresib
|
DB14970 |
[Alobresib is under investigation in clinical trial NCT02607228 (Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GS-5829 as a Single Agent and In Combination With Enzalutamide in Participants With Metastatic Castrate-Resistant Prostate Cancer).] |
|
Methamidophos
|
DB14972 |
[Methamidophos is under investigation in clinical trial NCT03223753 (Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia in First Remission).] |
|
Acetoxolone
|
DB13640 |
|
|
Trehalose
|
DB12310 |
[Cabaletta has been used in trials studying the treatment of Oculopharyngeal Muscular Dystrophy.] |
|
Metisazone
|
DB13641 |
|
|
Iomazenil
|
DB14971 |
[Iomazenil is under investigation in clinical trial NCT01590277 (Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans).] |
|
Pimecrolimus
|
DB00337 |
[Pimecrolimus is an immunomodulating agent that was first marketed by Novartis under the trade name Elidel. It is now promoted in Canada by Galderma since early 2007. It is currently available as a topic cream used in the treatment of atopic dermatitis (eczema).] |
|
Nanaomycin D
|
DB01668 |
|
