|
Peg-100 stearate
|
DB11225 |
|
|
Liquidambar styraciflua resin
|
DB11224 |
|
|
Tisagenlecleucel
|
DB13881 |
[Tisagenlecleucel is a CD19-directed genetically modified autologous T cell immunotherapy, or a CAR-T cell therapy for B-cell acute lymphoblastic leukemia. It was granted approval by FDA in August 2017 under the market name Kymriah. Tisagenlecleucel is an immunocellular therapy that involves autologous T cells that are collected from each individual patient and genetically engineered to express a specific protein called a chimeric antigen receptor (CAR) that specifically target CD19 antigens. Modified T cells are infused back into the patient's body. These CD19-directed chimeric antigen receptors (CD19 CAR-T cells) direct the T cells to targt and kill leukiemia cells that express a specific antigen (CD19) on the cell surface.
In a multicenter clinical trial involving pediatric and young adult patients with relapsed or refractory B-cell precursor ALL, the overall remission rate within three months of treatment was 83 percent [L942].] |
|
Taladegib
|
DB12550 |
[Taladegib has been used in trials studying the treatment of Solid Tumor, COLON CANCER, BREAST CANCER, Advanced Cancer, and Rhabdomyosarcoma, among others.] |
|
Tolu balsam
|
DB11223 |
|
|
Methyl nicotinate
|
DB13882 |
[Methyl nicotinate is the methyl ester of [DB00627] that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation. For veterinary purposes, methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains [F64].] |
|
Idazoxan
|
DB12551 |
[Idazoxan has been used in trials studying the basic science of Molecular Imaging, Alzheimer Disease, and Major Depressive Disorder.] |
|
Coral snake (micrurus fulvius) immune globulin antivenin (equine)
|
DB13883 |
[North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of envenomation caused by North American coral snake bites. It is intravenously administered so that the antivenin binds to and neutralizes coral snake venom.
The antivenin is a refined, concentrated, and lyophilized preparation of serum globulins obtained by fractionating blood from healthy horses that have been immunized with eastern coral snake (Micrurus fulvius fulvius) venom [FDA Label]. Prior to lyophilization, the product contains 0.25% phenol and 0.005% thiomerosal (mercury derivative) [FDA Label].] |
|
Benzoin resin
|
DB11222 |
[Benzoin resin is a balsamic resin obtained from the bark of several species of trees in the genus _Styrax_. There are two common kinds of benzoin, benzoin Siam and benzoin Sumatra, that are obtained from different species of the _Styrax_ tree. Benzoin resin differs from the chemical compound benzoin, which is derived from benzoin resin; however, the resin does not contain this compound (see [DB14020]). While benzoin resin is used as a common ingredient in incense-making and perfumery, it is also used clinically as a mild antiseptic agent in over-the-counter products to clean sores, cuts, wounds, and skin abrasions as tincture of benzoin, or benzoin in a solution of alcohol. Tincture of benzoin solution is a topical adhesive agent used to provide tackiness and enhance the adhesive property of tape.] |
|
Mazindol
|
DB00579 |
[Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only approved in the United States for the treatment of Duchenne muscular dystrophy, and is not marketed or available in the United States for use in the treatment of obesity.] |
|
Carbenicillin
|
DB00578 |
[Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.] |
|
Clonidine
|
DB00575 |
[Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246]
Clonidine was granted FDA approval on 3 September 1974.[L7237]] |
|
Fenfluramine
|
DB00574 |
[Fenfluramine is an appetite suppressant that was previously used in the treatment of obesity. After reports of heart valve disease and pulmonary hypertension, including a condition known as cardiac fibrosis, it was withdrawn from the U.S. market in 1997 due to safety reasons.] |
|
Valaciclovir
|
DB00577 |
[Valaciclovir (valacyclovir), also known as _Valtrex_, is an antiviral drug that has been used to manage and treat various herpes infections for more than 2 decades. It was initially approved by the FDA in 1995 [FDA label] and marketed by GlaxoSmithKline [L5671]. Valacyclovir is the L-valine ester of aciclovir. It is a member of the purine (guanine) nucleoside analog drug class [F3949]. This class of drugs forms an important part of hepatitis, HIV, and cytomegalovirus drug regimens [A175900].
One major use of valacyclovir is the treatment of genital herpes episodes or outbreaks. Genital herpes is a frequently diagnosed sexually transmitted disease which currently affects more than 400 million individuals worldwide. It is caused by infection with the herpes simplex virus (HSV). Infection with this virus is lifelong with periodic episodes of reactivation [A175903].] |
|
Sulfamethizole
|
DB00576 |
[A sulfathiazole antibacterial agent.] |
|
Propranolol
|
DB00571 |
[Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907]
Propranolol was granted FDA approval on 13 November 1967.[L6904]] |
|
Vinblastine
|
DB00570 |
[Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)] |
|
Fenoprofen
|
DB00573 |
[An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.] |
|
Atropine
|
DB00572 |
[An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae.] |
|
Aluminum sulfate
|
DB11239 |
[Aluminum (Al), also spelled aluminum, chemical element, a lightweight, silvery-white metal of main Group 13 (IIIa, or boron group) of the periodic table [L2148].
It is a chemical agent used in water purification, the pH regulation of garden soil, and other commercial or industrial applications. Medically, it is primarily used as a coagulating agent in minor cuts and abrasions as well as deodorant [L2144].
Aluminum (Al) is ubiquitous and represents the third most common element in the Earth’s crust. It most commonly exists in a combined state with various other elements. Al is found in materials used in the pharmaceutical industry, and in manufactured foodstuffs, cosmetics, and tap water. By overcoming the body barriers, Al may infiltrate into the blood and lead to toxic effects in liver, bone and the central nervous system [L2145].] |
