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Aluminum zirconium octachlorohydrex gly
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DB11200 |
[Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent [L2705], [L2706]. It diffuses into the sweat pores and prevents perspiration (sweat) from leaving the pores. The anhydrous form of the compound also has water-absorbing properties. Currently, the FDA allows the inclusion of this substance in concentrations of up to 20% in antiperspirants [L2012].
Interestingly, this chemical has been studied in relation to its possible impact on the microbiome of the human underarms [A32967].] |
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Hydroxyzine
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DB00557 |
[Hydroxyzine is a histamine H1 receptor antagonist that exhibits sedative, anxiolytic, tranquilizing, and antiemetic properties.[A187589] It is commonly used in allergic and inflammatory conditions, such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus. The active metabolite of hydroxyzine, [cetirizine], is also available as an active ingredient in allergic medications. Hydroxyzine is also used for generalized anxiety disorder, tension caused by psychoneurosis, and other conditions with manifestations of anxiety.[L9677]
Oral and intramuscular formulations of hydroxyzine are available for therapeutic use; however, oral administration of the drug is more common.] |
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4-[5-(Trans-4-Aminocyclohexylamino)-3-Isopropylpyrazolo[1,5-a]Pyrimidin-7-Ylamino]-N,N-Dimethylbenzenesulfonamide
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DB01888 |
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Perflutren
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DB00556 |
[Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.] |
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N,N-[2,5-O-Dibenzyl-glucaryl]-DI-[1-amino-indan-2-OL]
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DB01887 |
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Bosentan
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DB00559 |
[Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.] |
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Zanamivir
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DB00558 |
[A guanido-neuraminic acid that is used to inhibit neuraminidase.] |
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16,17-Androstene-3-Ol
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DB01889 |
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2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One
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DB01884 |
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Methoxsalen
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DB00553 |
[A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.] |
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Pentostatin
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DB00552 |
[A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.] |
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N-(Sulfanylacetyl)Tyrosylprolylmethioninamide
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DB01883 |
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Lamotrigine
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DB00555 |
[Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. In the US, lamotrigine is available as oral tablets under the market name Lamictal. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. While lamotrigine is primarily indicated for epilepsy and bipolar disorders, there is evidence that it could have some clinical efficacy in some neuropathic pain states. Lamotrigine is also used as an off-label drug in treating other neurologic and psychiatric pathologies like borderline personality disorder [A31737]. The exact mechanism of action of lamotrigine is not fully elucidated, as it may have multiple cellular actions that contribute to its broad clinical efficacy.] |
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Piroxicam
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DB00554 |
[A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.] |
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D-Galctopyranosyl-1-On
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DB01885 |
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3,4-Dihydroxycinnamic Acid
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DB01880 |
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(2s)-2-Amino-4-(Methylsulfanyl)-1-Pyridin-2-Ylbutane-1,1-Diol
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DB01882 |
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Acetohydroxamic acid
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DB00551 |
[Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.] |
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2-Methylpentane-1,2,4-Triol
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DB01881 |
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Propylthiouracil
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DB00550 |
[A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)] |
