|
Flumethasone
|
DB00663 |
[Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.] |
|
2-(Pyrido[1,2-E]Purin-4-Yl)Amino-Ethanol
|
DB01994 |
|
|
Trimethobenzamide
|
DB00662 |
[Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.] |
|
N-(5'-Phosphopyridoxyl)-D-Alanine
|
DB01993 |
|
|
3-Methylpyridine
|
DB01996 |
|
|
Nilutamide
|
DB00665 |
[Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.] |
|
Sulfametopyrazine
|
DB00664 |
[Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.] |
|
5-methylcytidine 5'-monophosphate
|
DB01995 |
|
|
Cholesterol sulfate
|
DB01990 |
[Component of human seminal plasma & spermatozoa.] |
|
Verapamil
|
DB00661 |
[Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced into therapy in the early 1960s.[A188514] It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs like [diltiazem] and [flunarizine], but is chemically unrelated to other cardioactive medications.[L8791] Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer, each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold greater potency than the R-enantiomer, but is metabolized at a higher rate.[A188435]] |
|
Coenzyme A
|
DB01992 |
[Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it, or a thioester form of it, as a substrate. It is used as a supplement for the hypothetical treatment of acne.] |
|
Metaxalone
|
DB00660 |
[Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous system depression. Metaxalone is associated with few side effects and is available as a 800 mg scored tablet.] |
|
TU-514
|
DB01991 |
|
|
BMS-582949
|
DB12696 |
[BMS-582949 has been investigated for the treatment of Psoriasis.] |
|
Pidotimod
|
DB11364 |
[Pidotimod is a synthetic dipeptide with immunomodulatory properties.] |
|
Alectinib
|
DB11363 |
[Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. Inhibition of ALK prevents phosphorylation and subsequent downstream activation of STAT3 and AKT resulting in reduced tumour cell viability.
Approved under accelerated approval in 2015, alectinib is indicated for use in patients who have progressed on or were not tolerant of crizotinib, which is associated with the development of resistance.] |
|
Methylselenocysteine
|
DB12697 |
[Methylselenocysteine has been used in trials studying the prevention of Prostate Carcinoma and No Evidence of Disease.] |
|
Selexipag
|
DB11362 |
[Selexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce risk of hospitalization. PAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes. Marketed by Actelion Pharmaceuticals under brand name Uptravi, selexipag and its active metabolite, ACT-333679 (MRE-269), act as agonists of the prostacyclin receptor to increase vasodilation in the pulmonary circulation and decrease elevated pressure in the blood vessels supplying blood to the lungs.] |
|
Ibalizumab
|
DB12698 |
[Ibalizumab (also known as _ibalizumab-uiyk_ and formerly known as TNX-355) is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells, preventing HIV particle entry into the lymphocytes. It is an advanced and current antibody in development for the treatment of HIV/AIDS. It has been developed by Taimed biologics and Theratechnologies [L1558, L1554].
This drug was approved in March 2018 for the management of treatment-resistant HIV [L1554].] |
|
Balugrastim
|
DB12699 |
[Balugrastim has been used in trials studying the treatment of Solid Tumors.] |
