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Caramiphen
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DB11504 |
[Caramiphen is a cholinergic antagonist used in Parkinson's disease. Additionally, it is used, in combination with [phenylpropanolamine], as a cough suppressant and nasal decongestant for the symptomatic treatment of seasonal respiratory conditions.] |
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UK-500001
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DB12837 |
[UK-500,001 has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive.] |
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Butacaine
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DB11502 |
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Tetrasul
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DB12838 |
[Tetrasul has been used in trials studying the treatment of Erythematous (Type One) Rosacea.] |
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Pegvaliase
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DB12839 |
[Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from _Anabaena variabilis_ that converts phenylalanine to ammonia and _trans_-cinnamic acid [A33284]. Both the U.S. Food and Drug Administration and European Medicines Agency approved pegvaliase-pqpz in May 2018 for the treatment of adult patients with phenylketonuria (PKU). Phenylketonuria is a rare autosomal recessive disorder that is characterized by deficiency of the enzyme phenylalanine hydroxylase (PAH) [A33284] and affects about 1 in 10,000 to 15,000 people in the United States [L2925]. PAH deficiency and inability to break down an amino acid phenylalanine (Phe) leads to elevated blood phenylalanine concentrations and accumulation of neurotoxic Phe in the brain, causing chronic intellectual, neurodevelopmental and psychiatric disabilities if untreated [A33284]. Individuals with PKU also need to be under a strictly restricted diet as Phe is present in foods and products with high-intensity sweeteners [L2925]. The primary goal of lifelong treatment of PKU, as recommended by the American College of Medical Genetics and Genomics (ACMG) guidelines, is to maintain blood Phe concentration in the range of 120 µmol/L to 3690 µmol/L [A33286]. Pegvaliase-pqpz, or PEGylated pegvaliase, is used as a novel enzyme substitution therapy and is marketed as Palynziq for subcutanoues injection. It is advantageous over currently available management therapies for PKU, such as [DB00360], that are ineffective to many patients due to long-term adherence issues or inadequate Phe-lowering effects [A33284]. The presence of a PEG moiety in pegvaliase-pqpz allows a reduced immune response and improved pharmacodynamic stability [A33284].] |
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Prednimustine
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DB12832 |
[Prednimustine has been used in trials studying the treatment of Lymphoma.] |
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Cloprostenol
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DB11507 |
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Tandospirone
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DB12833 |
[Tandospirone has been used in trials studying the treatment of Schizophrenia.] |
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Secnidazole
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DB12834 |
[Secnidazole is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer terminal elimination half-life than antimicrobial agents in this class [A27210]. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria and protozoa. In September 2017, FDA granted approval to secnidazole under the market name Solosec as a single-dose oral treatment for bacterial vaginosis, which is a common vaginal infection in women aged 15 to 44 years. The antimicrobial therapy is only intended to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria [FDA Label].] |
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Olipudase alfa
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DB12835 |
[Olipudase alfa has been used in trials studying the treatment of Sphingomyelin Lipidosis and Human Acid Sphingomyelinase Deficiency.] |
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Cebranopadol
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DB12830 |
[Cebranopadol has been used in trials studying the treatment of Pain, Neoplasms, and Chronic Pain.] |
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Gabexate
|
DB12831 |
[Gabexate is a synthetic serine protease inhibitor which has been used as an anticoagulant. It also known to decrease production of inflammatory cytokines. Gabexate has been investigated for use in cancer, ischemia-reperfusion injury, and pancreatitis [A19218] [A19219] [A19220].] |
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Drostanolone
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DB00858 |
[Drostanolone (also known as dromostanolone) is a potent synthetic androgenic anabolic steroid similar to testosterone. Drostanolone is indicated in postmenopausal women with recurrent breast cancer, in a combined hormone therapy.] |
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Terbinafine
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DB00857 |
[Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.[A1279] Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.[A1279,A1281,L9068]
Terbinafine hydrochloride was granted FDA approval on 30 December 1992.[L9064]] |
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Penicillamine
|
DB00859 |
[Penicillamine is a pharmaceutical of the chelator class. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). It is an α-amino acid metabolite of penicillin, although it has no antibiotic properties.] |
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Levorphanol
|
DB00854 |
[A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.] |
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Temozolomide
|
DB00853 |
[Temozolomide (Temodar and Temodal) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumor. Temozolomide is not active until it is converted at physiologic pH to the active form, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC).] |
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Chlorphenesin
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DB00856 |
|
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Aminolevulinic acid
|
DB00855 |
[A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]] |
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Perphenazine
|
DB00850 |
[An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.] |
