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Entrectinib
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DB11986 |
[Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor.[L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positive solid tumors.[L8207] Entrectinib's approved use is meant as a last line of therapy due to its accelerated approval based on early trial data. This therapy offers benefit over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib] due to a wider range of targets.[A183929]] |
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(3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
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DB07007 |
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19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one
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DB08338 |
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Dapaconazole
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DB11985 |
[Dapaconazole has been used in trials studying the treatment of Tinea Pedis.] |
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Hazelnut
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DB10654 |
[Hazelnut allergenic extract is used in allergenic testing.] |
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4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE
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DB07008 |
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6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
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DB08339 |
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2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL
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DB07009 |
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Leek
|
DB10659 |
[Leek allergenic extract is used in allergenic testing.] |
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Benznidazole
|
DB11989 |
[Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017 [L939]. It is the first treatment made available in the United States for Chagas disease.] |
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Papaya
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DB10658 |
[Papaya allergenic extract is used in allergenic testing.] |
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Carbon Black
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DB11980 |
[Carbon Black has been used in trials studying Atopic Hypersensitivity and Hypersensitivity, Immediate.] |
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Cashew
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DB10653 |
[Cashew allergenic extract is used in allergenic testing.] |
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Letaxaban
|
DB11984 |
[Letaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome.] |
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Turnip
|
DB10652 |
[Turnip allergenic extract is used in allergenic testing.] |
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Placulumab
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DB11983 |
[Placulumab has been used in trials studying the treatment of Rheumatoid Arthritis.] |
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GDC-0623
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DB11982 |
[GDC-0623 has been used in trials studying the treatment of Solid Cancers.] |
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Rhubarb
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DB10651 |
[Rhubarb allergenic extract is used in allergenic testing.] |
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Raphanus sativus
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DB10650 |
[Radish allergenic extract is used in allergenic testing.] |
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Elamipretide
|
DB11981 |
[Elamipretide has been used in trials studying the treatment of Leber's Hereditary Optic Neuropathy.] |
